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Clinical Medicine
Scientific Show Stopper
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238 Posts
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Tracking T cells
Christian Bauer, Edward Kim, and colleagues use a murine model of adoptive T cell therapy to track T cell populations within tumor tissue…
Published May 8, 2014
Scientific Show Stopper
Limiting hypoxia-induced renal damage
Using murine models, Pinelopi Kapitsinou and colleagues reveal that endothelial HIF-2 protects the kidney from ischemia-induced damage…
Published May 1, 2014
Scientific Show Stopper
Out with the old
Tania Zaglia, Giulia Milan, and colleagues demonstrate a role for atrogin-1 in maintaining cardiac proetostasis…
Published May 1, 2014
Scientific Show Stopper
Plasmalogens in the periphery
Using a murine model of rhizomelic chrondrodysplasia punctata, Pedro Brites and colleagues investigate the role of plasmalogens in the peripheral nervous system….
Published April 24, 2014
Scientific Show Stopper
RSV blocked by double-stapled peptide
Gregory Bird, Sandhya Boyapalle, and colleagues developed a double-stapled RSV F peptide that blocks RSV infection in cells and murine models…
Published April 17, 2014
Scientific Show Stopper
Brown fat whitening
Using a murine model, Ippei Shimizu and colleagues demonstrate that diet-induced obesity leads to a “whitening” phenotype in brown adipose tissue that is characterized by reduced capillary volume, hypoxia, mitochondrial dysfunction...
Published April 8, 2014
Scientific Show Stopper
An unconventional EMT
Cunxi Li, Haiting Ma, and colleagues reveal that endogenous placental-specific 8 (PLAC8) localizes to the apical membrane of the intestinal epithelium in healthy tissue, while in colorectal cancer PLAC8 is cytosolic and promotes EMT...
Published April 1, 2014
Scientific Show Stopper
Suppressing colon cancer
Marion Lapierre and colleagues determined that the transcriptional cofactor RIP140 positively regulates APC and genes encoding members of the β-catenin degradation complex....
Published March 25, 2014
Scientific Show Stopper
Repairing damaged nerves
Mitra Lavasani and colleagues demonstrate that human-derived MDSPCs (hMDSPCs) can be induced to adopt neuronal and glial characteristics...
Published March 18, 2014
Scientific Show Stopper
Making connections
Valter Tucci and colleagues identified dominant β-catenin mutations in patients with intellectual disability that all displayed a syndrome characterized by mild to severe intellectual disability, autism, lack of muscle tone, progressive limb spasticity, a
Published March 10, 2014
Scientific Show Stopper
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