[HTML][HTML] Death begets failure in the heart
Recently, low—but abnormal—rates of cardiomyocyte apoptosis have been observed in
failing human hearts. Genetic and pharmacological studies suggest that this cell death is
causally linked to heart failure in rodent models. Herein, we review these data and discuss
potential therapeutic implications.
failing human hearts. Genetic and pharmacological studies suggest that this cell death is
causally linked to heart failure in rodent models. Herein, we review these data and discuss
potential therapeutic implications.
Recently, low — but abnormal — rates of cardiomyocyte apoptosis have been observed in failing human hearts. Genetic and pharmacological studies suggest that this cell death is causally linked to heart failure in rodent models. Herein, we review these data and discuss potential therapeutic implications.
The Journal of Clinical Investigation