A METTL3–METTL14 complex mediates mammalian nuclear RNA N6-adenosine methylation
Nature chemical biology, 2014•nature.com
Abstract N 6-methyladenosine (m6A) is the most prevalent and reversible internal
modification in mammalian messenger and noncoding RNAs. We report here that human
methyltransferase-like 14 (METTL14) catalyzes m6A RNA methylation. Together with
METTL3, the only previously known m6A methyltransferase, these two proteins form a stable
heterodimer core complex of METTL3–METTL14 that functions in cellular m6A deposition on
mammalian nuclear RNAs. WTAP, a mammalian splicing factor, can interact with this …
modification in mammalian messenger and noncoding RNAs. We report here that human
methyltransferase-like 14 (METTL14) catalyzes m6A RNA methylation. Together with
METTL3, the only previously known m6A methyltransferase, these two proteins form a stable
heterodimer core complex of METTL3–METTL14 that functions in cellular m6A deposition on
mammalian nuclear RNAs. WTAP, a mammalian splicing factor, can interact with this …
Abstract
N6-methyladenosine (m6A) is the most prevalent and reversible internal modification in mammalian messenger and noncoding RNAs. We report here that human methyltransferase-like 14 (METTL14) catalyzes m6A RNA methylation. Together with METTL3, the only previously known m6A methyltransferase, these two proteins form a stable heterodimer core complex of METTL3–METTL14 that functions in cellular m6A deposition on mammalian nuclear RNAs. WTAP, a mammalian splicing factor, can interact with this complex and affect this methylation.
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