[HTML][HTML] Single-cell atlas of hepatic T cells reveals expansion of liver-resident naive-like CD4+ T cells in primary sclerosing cholangitis
T Poch, J Krause, C Casar, T Liwinski, L Glau… - Journal of …, 2021 - Elsevier
Background & Aims Little is known about the composition of intrahepatic immune cells and
their contribution to the pathogenesis of primary sclerosing cholangitis (PSC). Herein, we
aimed to create an atlas of intrahepatic T cells and thereby perform an in-depth
characterization of T cells in inflamed human liver. Methods Different single-cell RNA
sequencing methods were combined with in silico analyses on intrahepatic and peripheral T
cells from patients with PSC (n= 11) and healthy donors (HDs, n= 4). Multi-parameter flow …
their contribution to the pathogenesis of primary sclerosing cholangitis (PSC). Herein, we
aimed to create an atlas of intrahepatic T cells and thereby perform an in-depth
characterization of T cells in inflamed human liver. Methods Different single-cell RNA
sequencing methods were combined with in silico analyses on intrahepatic and peripheral T
cells from patients with PSC (n= 11) and healthy donors (HDs, n= 4). Multi-parameter flow …