[CITATION][C] Inhibitory effect of selenomethionine on carcinogenesis in the model of human colorectal cancer in vitro and its link to the Wnt/β-catenin pathway.
E Korbut, A Ptak-Belowska… - Acta Biochimica …, 2018 - ojs.ptbioch.edu.pl
Selenium compounds have been implicated as anticancer agents; however, the mechanism
of their inhibitory action against cancer development has not been extensively investigated.
The constitutive activation of the Wnt/β-catenin pathway is a central event in colorectal
carcinogenesis. In this pathway, the excessive cell proliferation is initiated by the generation
of β-catenin followed by overexpression of proto-oncogenes such as c-Myc. It is believed
that under physiological conditions the level of c-Myc is efficiently controlled by accessibility …
of their inhibitory action against cancer development has not been extensively investigated.
The constitutive activation of the Wnt/β-catenin pathway is a central event in colorectal
carcinogenesis. In this pathway, the excessive cell proliferation is initiated by the generation
of β-catenin followed by overexpression of proto-oncogenes such as c-Myc. It is believed
that under physiological conditions the level of c-Myc is efficiently controlled by accessibility …
