Mouse models of bone healing: fracture, marrow ablation, and distraction osteogenesis
K Lybrand, B Bragdon… - Current protocols in …, 2015 - Wiley Online Library
K Lybrand, B Bragdon, L Gerstenfeld
Current protocols in mouse biology, 2015•Wiley Online LibraryThree commonly used murine surgical models of bone healing [closed fracture with
intramedullary fixation, distraction osteogenesis (DO), and marrow ablation by reaming] are
presented. Detailed surgical protocols for each model are outlined. The nature of the
regenerative processes and the types of research questions that may be addressed with
these models are briefly outlined. The relative strengths and weaknesses of these models
are compared to a number of other surgical models that are used to address similar …
intramedullary fixation, distraction osteogenesis (DO), and marrow ablation by reaming] are
presented. Detailed surgical protocols for each model are outlined. The nature of the
regenerative processes and the types of research questions that may be addressed with
these models are briefly outlined. The relative strengths and weaknesses of these models
are compared to a number of other surgical models that are used to address similar …
Abstract
Three commonly used murine surgical models of bone healing [closed fracture with intramedullary fixation, distraction osteogenesis (DO), and marrow ablation by reaming] are presented. Detailed surgical protocols for each model are outlined. The nature of the regenerative processes and the types of research questions that may be addressed with these models are briefly outlined. The relative strengths and weaknesses of these models are compared to a number of other surgical models that are used to address similar research questions. © 2015 by John Wiley & Sons, Inc.
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