[HTML][HTML] Biosynthetic Modulation of Sialic Acid-dependent Virus-Receptor Interactions of Two Primate Polyoma Viruses (∗)
OT Keppler, P Stehling, M Herrmann, H Kayser… - Journal of Biological …, 1995 - ASBMB
Sialic acids are essential components of the cell surface receptors of many microorganisms
including viruses. A synthetic, N-substituted D-mannosamine derivative has been shown to
act as precursor for structurally altered sialic acid incorporated into glycoconjugates in vivo
(Kayser, H., Zeitler, R., Kannicht, C., Grunow, D., Nuck, R., and Reutter, W.(1992) J. Biol.
Chem. 267, 16934-16938). In this study we have analyzed the potential of three different
sialic acid precursor analogues to modulate sialic acid-dependent virus receptor function on …
including viruses. A synthetic, N-substituted D-mannosamine derivative has been shown to
act as precursor for structurally altered sialic acid incorporated into glycoconjugates in vivo
(Kayser, H., Zeitler, R., Kannicht, C., Grunow, D., Nuck, R., and Reutter, W.(1992) J. Biol.
Chem. 267, 16934-16938). In this study we have analyzed the potential of three different
sialic acid precursor analogues to modulate sialic acid-dependent virus receptor function on …