Background: Difficulty integrating home and workplace expectations may explain gender differences in academic success and attrition of promising physician–researchers (1–3). Institutions have piloted creative interventions to help those facing time-sensitive productivity and family pressures, but the problem persists nationwide (4, 5). The Doris Duke Charitable Foundation created an innovative new national program to support junior physician–researchers facing substantial extraprofessional challenges.

Objective: To describe the program's design, goals, and first-year experiences.

Methods and Findings: In 2015, the Doris Duke Charitable Foundation solicited proposals for the Fund to Retain Clinical Scientists, seeking to support programs at medical schools to facilitate the success and retention of physician–researchers facing substantial caregiving challenges. The foundation received 72 letters of intent and 61 full applications; it funded 10 sites. Five-year grants of $540 000 support approximately 6 junior physician–researchers at each site (recommended support, approximately $30 000 to $50 000 per year for 1 to 2 years). Funds were designated for research support, not child care or elder care costs.