Chronic graft-versus-host disease as a model for scleroderma: II. Mast cell depletion with deposition of immunoglobulins in the skin and fibrosis
HN Claman, BD Jaffee, JC Huff, RAF Clark - Cellular immunology, 1985 - Elsevier
We explored the pathologic changes in the skin of mice undergoing a chronic graft-
versushost (GVH) reaction. In rodents and in man, chronic GVH includes the deposition of
excess collagen in the skin—a reaction which resembles idiopathic scleroderma. GVH
disease across minor histocompatibility barriers was produced by injecting B10. D2 cells
into irradiated BALB/c mice. These strains are identical at the H-2 and Mls loci but differ in
minor histocompatibility antigens. Control BALB/c mice received irradiation and BALB/c …
versushost (GVH) reaction. In rodents and in man, chronic GVH includes the deposition of
excess collagen in the skin—a reaction which resembles idiopathic scleroderma. GVH
disease across minor histocompatibility barriers was produced by injecting B10. D2 cells
into irradiated BALB/c mice. These strains are identical at the H-2 and Mls loci but differ in
minor histocompatibility antigens. Control BALB/c mice received irradiation and BALB/c …