Immunopathogenesis of primary graft dysfunction after lung transplantation
A Bharat, D Kreisel - The Annals of Thoracic Surgery, 2018 - annalsthoracicsurgery.org
Primary graft dysfunction (PGD) has emerged as one of the most important risk factors for
short-term death after lung transplantation and chronic lung allograft dysfunction [1]. PGD is
associated with a robust inflammatory cascade, which not only causes direct damage to the
allograft but also augments alloimmunity as well as tissue-restricted autoimmunity, ultimately
predisposing to chronic rejection. Because PGD is known to affect more than half of the
recipients within the first 72 hours, the disease burden of PGD after lung transplantation is …
short-term death after lung transplantation and chronic lung allograft dysfunction [1]. PGD is
associated with a robust inflammatory cascade, which not only causes direct damage to the
allograft but also augments alloimmunity as well as tissue-restricted autoimmunity, ultimately
predisposing to chronic rejection. Because PGD is known to affect more than half of the
recipients within the first 72 hours, the disease burden of PGD after lung transplantation is …