The bm12 inducible model of systemic lupus erythematosus (SLE) in C57BL/6 mice
J Klarquist, EM Janssen - JoVE (Journal of Visualized Experiments), 2015 - jove.com
Systemic lupus erythematosus (SLE) is an autoimmune disease with diverse clinical and
immunological manifestations. Several spontaneous and inducible animal models mirror
common components of human disease, including the bm12 transfer model. Upon transfer
of bm12 splenocytes or purified CD4 T cells, C57BL/6 mice rapidly develop large
frequencies of T follicular helper cells (Tfh), germinal center (GC) B cells, and plasma cells
followed by high levels of circulating anti-nuclear antibodies. Since this model utilizes mice …
immunological manifestations. Several spontaneous and inducible animal models mirror
common components of human disease, including the bm12 transfer model. Upon transfer
of bm12 splenocytes or purified CD4 T cells, C57BL/6 mice rapidly develop large
frequencies of T follicular helper cells (Tfh), germinal center (GC) B cells, and plasma cells
followed by high levels of circulating anti-nuclear antibodies. Since this model utilizes mice …