Sphingolipids in neurodegeneration (with focus on ceramide and S1P)
G Wang, E Bieberich - Advances in biological regulation, 2018 - Elsevier
For many decades, research on sphingolipids associated with neurodegenerative disease
focused on alterations in glycosphingolipids, particularly glycosylceramides (cerebrosides),
sulfatides, and gangliosides. This seemed quite natural since many of these glycolipids are
constituents of myelin and accumulated in lipid storage diseases (sphingolipidoses)
resulting from enzyme deficiencies in glycolipid metabolism. With the advent of recognizing
ceramide and its derivative, sphingosine-1-phosphate (S1P), as key players in lipid cell …
focused on alterations in glycosphingolipids, particularly glycosylceramides (cerebrosides),
sulfatides, and gangliosides. This seemed quite natural since many of these glycolipids are
constituents of myelin and accumulated in lipid storage diseases (sphingolipidoses)
resulting from enzyme deficiencies in glycolipid metabolism. With the advent of recognizing
ceramide and its derivative, sphingosine-1-phosphate (S1P), as key players in lipid cell …
