[HTML][HTML] The c-Cbl ubiquitin ligase regulates nuclear β-catenin and angiogenesis by its tyrosine phosphorylation mediated through the Wnt signaling pathway
S Shivanna, I Harrold, M Shashar, R Meyer… - Journal of Biological …, 2015 - ASBMB
Wnt signaling plays important roles in both the tumor-induced angiogenesis and
tumorigenesis through the transcriptionally active nuclear β-catenin. Recently, c-Cbl was
identified as a unique E3 ubiquitin ligase targeting the active nuclear β-catenin. However,
little is known about the molecular mechanisms by which c-Cbl regulates ubiquitination and
degradation of active β-catenin. Here, we demonstrate that Wnt activation promotes the
phosphorylation of c-Cbl at tyrosine 731 (Tyr-731), which increases c-Cbl dimerization and …
tumorigenesis through the transcriptionally active nuclear β-catenin. Recently, c-Cbl was
identified as a unique E3 ubiquitin ligase targeting the active nuclear β-catenin. However,
little is known about the molecular mechanisms by which c-Cbl regulates ubiquitination and
degradation of active β-catenin. Here, we demonstrate that Wnt activation promotes the
phosphorylation of c-Cbl at tyrosine 731 (Tyr-731), which increases c-Cbl dimerization and …
