The cell biology of APOL1
JF O'Toole, LA Bruggeman, S Madhavan… - Seminars in nephrology, 2017 - Elsevier
The association of variants in the APOL1 gene, which encodes apolipoprotein L1 (APOL1),
with progressive nondiabetic kidney diseases in African Americans has prompted intense
investigation into the function (s) of APOL1. APOL1 is an innate immune effector that protects
human beings from infection by some trypanosomal parasites. We review the data
characterizing APOL1 trypanolytic function, which has been a basis for studies of APOL1
function in mammalian cells. Subsequently, we discuss the studies that use animal models …
with progressive nondiabetic kidney diseases in African Americans has prompted intense
investigation into the function (s) of APOL1. APOL1 is an innate immune effector that protects
human beings from infection by some trypanosomal parasites. We review the data
characterizing APOL1 trypanolytic function, which has been a basis for studies of APOL1
function in mammalian cells. Subsequently, we discuss the studies that use animal models …