Clinical features and histology of apolipoprotein L1-associated nephropathy in the FSGS clinical trial
Genetic variants in apolipoprotein L1 (APOL1) confer risk for kidney disease. We sought to
better define the phenotype of APOL1-associated nephropathy. The FSGS Clinical Trial
involved 138 children and young adults who were randomized to cyclosporin or
mycophenolate mofetil plus pulse oral dexamethasone with a primary outcome of
proteinuria remission. DNA was available from 94 subjects who were genotyped for APOL1
renal risk variants, with two risk alleles comprising the risk genotype. Two APOL1 risk alleles …
better define the phenotype of APOL1-associated nephropathy. The FSGS Clinical Trial
involved 138 children and young adults who were randomized to cyclosporin or
mycophenolate mofetil plus pulse oral dexamethasone with a primary outcome of
proteinuria remission. DNA was available from 94 subjects who were genotyped for APOL1
renal risk variants, with two risk alleles comprising the risk genotype. Two APOL1 risk alleles …
