[HTML][HTML] Trypanosome lytic factor-1 initiates oxidation-stimulated osmotic lysis of Trypanosoma brucei brucei
AS Greene, SL Hajduk - Journal of Biological Chemistry, 2016 - ASBMB
Human innate immunity against the veterinary pathogen Trypanosoma brucei brucei is
conferred by trypanosome lytic factors (TLFs), against which human-infective T. brucei
gambiense and T. brucei rhodesiense have evolved resistance. TLF-1 is a subclass of high
density lipoprotein particles defined by two primate-specific apolipoproteins: the ion channel-
forming toxin ApoL1 (apolipoprotein L1) and the hemoglobin (Hb) scavenger Hpr
(haptoglobin-related protein). The role of oxidative stress in the TLF-1 lytic mechanism has …
conferred by trypanosome lytic factors (TLFs), against which human-infective T. brucei
gambiense and T. brucei rhodesiense have evolved resistance. TLF-1 is a subclass of high
density lipoprotein particles defined by two primate-specific apolipoproteins: the ion channel-
forming toxin ApoL1 (apolipoprotein L1) and the hemoglobin (Hb) scavenger Hpr
(haptoglobin-related protein). The role of oxidative stress in the TLF-1 lytic mechanism has …
