CCR2 signaling contributes to ischemia-reperfusion injury in kidney
K Furuichi, T Wada, Y Iwata, K Kitagawa… - Journal of the …, 2003 - journals.lww.com
Examined were CCR2-deficient mice to clarify the contribution of macrophages via
monocyte chemoattractant protein 1 (MCP-1 or CCL2)/CCR2 signaling to the pathogenesis
of renal ischemia-reperfusion injury. Also evaluated was the therapeutic effects via the
inhibition of MCP-1/CCR2 signaling with propagermanium (3-oxygermylpropionic acid
polymer) and RS-504393. Renal artery and vein of the left kidney were occluded with a
vascular clamp for 60 min. A large number of infiltrated cells and marked acute tubular …
monocyte chemoattractant protein 1 (MCP-1 or CCL2)/CCR2 signaling to the pathogenesis
of renal ischemia-reperfusion injury. Also evaluated was the therapeutic effects via the
inhibition of MCP-1/CCR2 signaling with propagermanium (3-oxygermylpropionic acid
polymer) and RS-504393. Renal artery and vein of the left kidney were occluded with a
vascular clamp for 60 min. A large number of infiltrated cells and marked acute tubular …
