Renal bone morphogenetic protein-7 protects against diabetic nephropathy
S Wang, M de Caestecker, J Kopp, G Mitu… - Journal of the …, 2006 - journals.lww.com
Longstanding diabetes causes renal injury with early dropout of podocytes, albuminuria,
glomerular and tubulointerstitial fibrosis, and progressive renal failure. The renal pathology
seems to be driven, in part, by TGF-β and is associated with a loss of renal bone
morphogenic protein-7 (BMP-7) expression. Here, the hypothesis that maintenance of renal
(especially podocyte) BMP-7 by transgenic expression reduces diabetic renal injury was
tested. Diabetic mice that expressed the phosphoenolpyruvate carboxykinase promoter …
glomerular and tubulointerstitial fibrosis, and progressive renal failure. The renal pathology
seems to be driven, in part, by TGF-β and is associated with a loss of renal bone
morphogenic protein-7 (BMP-7) expression. Here, the hypothesis that maintenance of renal
(especially podocyte) BMP-7 by transgenic expression reduces diabetic renal injury was
tested. Diabetic mice that expressed the phosphoenolpyruvate carboxykinase promoter …
