Mechanism of mannose toxicity
M de la Fuente, PF Peñas, A Sols - Biochemical and Biophysical Research …, 1986 - Elsevier
M de la Fuente, PF Peñas, A Sols
Biochemical and Biophysical Research Communications, 1986•ElsevierMannose toxicity in honeybees is due to a marked shortage of mannosephosphate
isomerase that leads to a large accumulation of mannose-6-P and a marked depletion of
ATP. Drosophila melanogaster and Ceratitis capitata are insensitive to mannose and have
excess of mannosephosphate isomerase over hexokinase. 2-Deoxyglucose is as toxic as
mannose for honeybees and is toxic also for the other insects studied, which supports the
conclusion that the mechanism of mannose toxicity involves large accumulation of a …
isomerase that leads to a large accumulation of mannose-6-P and a marked depletion of
ATP. Drosophila melanogaster and Ceratitis capitata are insensitive to mannose and have
excess of mannosephosphate isomerase over hexokinase. 2-Deoxyglucose is as toxic as
mannose for honeybees and is toxic also for the other insects studied, which supports the
conclusion that the mechanism of mannose toxicity involves large accumulation of a …
Mannose toxicity in honeybees is due to a marked shortage of mannosephosphate isomerase that leads to a large accumulation of mannose-6-P and a marked depletion of ATP. Drosophila melanogaster and Ceratitis capitata are insensitive to mannose and have excess of mannosephosphate isomerase over hexokinase. 2-Deoxyglucose is as toxic as mannose for honeybees and is toxic also for the other insects studied, which supports the conclusion that the mechanism of mannose toxicity involves large accumulation of a hexosephosphate.
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