Overexpression of cyclooxygenase-2 predisposes to podocyte injury
H Cheng, S Wang, YI Jo, CM Hao… - Journal of the …, 2007 - journals.lww.com
Abstract Increased podocyte cyclooxygenase-2 (COX-2) expression is seen in rats after
renal ablation and Thy-1 nephritis and in cultured murine podocytes in response to
mechanical stress. For investigation of whether COX-2 overexpression plays a role in
podocyte injury, transgenic B6/D2 mice in which COX-2 expression was driven by a nephrin
promoter were established. Selective upregulation of COX-2 expression in podocytes of
transgenic mouse kidneys was confirmed by immunoblotting and immunohistochemistry …
renal ablation and Thy-1 nephritis and in cultured murine podocytes in response to
mechanical stress. For investigation of whether COX-2 overexpression plays a role in
podocyte injury, transgenic B6/D2 mice in which COX-2 expression was driven by a nephrin
promoter were established. Selective upregulation of COX-2 expression in podocytes of
transgenic mouse kidneys was confirmed by immunoblotting and immunohistochemistry …
