Deficiency of the Nrf1 and Nrf2 transcription factors results in early embryonic lethality and severe oxidative stress
L Leung, M Kwong, S Hou, C Lee, JY Chan - Journal of Biological …, 2003 - ASBMB
Nrf1 and Nrf2 are members of the CNC family of bZIP transcription factors that exhibit
structural similarities, and they are co-expressed in a wide range of tissues during
development. Nrf2 has been shown to be dispensable for growth and development in mice.
Nrf2-deficient mice, however, are impaired in oxidative stress defense. We previously
showed that loss of Nrf1 function in mice results late gestational embryonic lethality. To
determine whether Nrf1 and Nrf2 have overlapping functions during early development and …
structural similarities, and they are co-expressed in a wide range of tissues during
development. Nrf2 has been shown to be dispensable for growth and development in mice.
Nrf2-deficient mice, however, are impaired in oxidative stress defense. We previously
showed that loss of Nrf1 function in mice results late gestational embryonic lethality. To
determine whether Nrf1 and Nrf2 have overlapping functions during early development and …
