[HTML][HTML] Thrombospondin-1 restrains neutrophil granule serine protease function and regulates the innate immune response during Klebsiella pneumoniae infection
Y Zhao, TF Olonisakin, Z Xiong, M Hulver, S Sayeed… - Mucosal …, 2015 - Elsevier
Neutrophil elastase (NE) and cathepsin G (CG) contribute to intracellular microbial killing
but, if left unchecked and released extracellularly, promote tissue damage. Conversely,
mechanisms that constrain neutrophil serine protease activity protect against tissue damage
but may have the untoward effect of disabling the microbial killing arsenal. The host
elaborates thrombospondin-1 (TSP-1), a matricellular protein released during inflammation,
but its role during neutrophil activation following microbial pathogen challenge remains …
but, if left unchecked and released extracellularly, promote tissue damage. Conversely,
mechanisms that constrain neutrophil serine protease activity protect against tissue damage
but may have the untoward effect of disabling the microbial killing arsenal. The host
elaborates thrombospondin-1 (TSP-1), a matricellular protein released during inflammation,
but its role during neutrophil activation following microbial pathogen challenge remains …
