Production of IL-1β and IL-1Ra as risk factors for susceptibility and progression of relapse-onset multiple sclerosis

BA de Jong, TWJ Huizinga, ELEM Bollen… - Journal of …, 2002 - Elsevier
Interleukin-1β (IL-1β) is present in multiple sclerosis (MS) lesions. Interleukin-1 receptor
antagonist (IL-1Ra) moderates the induction of experimental autoimmune encephalomyelitis
(EAE). Here, we show that families that are characterized by high IL-1β over IL-1Ra
production ratio are at 2.2-fold (95% CI, 1.0–4.8; p= 0.05) increased risk to have a patient
relative with relapse-onset MS than families with a low ratio. It is also related to the reduction
of volumetric magnetization transfer ratio (MTR) histogram height, a measure of …