A rare hereditary disorder, Fanconi anemia (FA), is caused by mutations in an array of
genes, which interact in a common FA pathway/network. These genes encode components
of the FA" core" complex, a key factor FancD2, the familial breast cancer suppressor
BRCA2/FancD1, and Brip1/FancJ helicase. Although BRCA2 is known to play a pivotal role
in homologous recombination repair by regulating Rad51 recombinase, the precise
functional relationship between BRCA2 and the other FA genes is unclear. Here we show …