Epithelial tenascin predicts obliterative airway disease
OE Päiväniemi, PK Maasilta, HS Alho… - The Journal of heart and …, 2008 - Elsevier
BACKGROUND: Epithelial cell injury, inflammation, fibrosis and airway obliteration result in
remodeling of terminal bronchi in post-transplant obliterative bronchiolitis. Tenascin as an
extracellular matrix glycoprotein is expressed in several remodeling processes. METHODS:
Heterotopic bronchial allografts of pigs were studied to assess tenascin expression during
development of post-transplant obliterative bronchiolitis. A total of 157 allografts or autograft
controls were serially obtained 2 to 28 days after transplantation and processed for histology …
remodeling of terminal bronchi in post-transplant obliterative bronchiolitis. Tenascin as an
extracellular matrix glycoprotein is expressed in several remodeling processes. METHODS:
Heterotopic bronchial allografts of pigs were studied to assess tenascin expression during
development of post-transplant obliterative bronchiolitis. A total of 157 allografts or autograft
controls were serially obtained 2 to 28 days after transplantation and processed for histology …