[HTML][HTML] HMGB1 is involved in chronic rejection of cardiac allograft via promoting inflammatory-like mDCs
H Zou, Y Yang, M Gao, B Zhang, B Ming, Y Sun… - American Journal of …, 2014 - Elsevier
Chronic rejection that leads to diffuse narrowing and occlusion of graft vessels is the most
important cause of morbidity and mortality following cardiac transplantation. The role and
underlying mechanism of high-mobility group box 1 (HMGB1), as an established
inflammatory mediator in acute rejection, remains poorly understood in chronic rejection.
Here, we assessed the effects and mechanisms of HMGB1 on the chronic rejection using
single MHC Class II-mismatched mouse cardiac transplantation model. It was found that …
important cause of morbidity and mortality following cardiac transplantation. The role and
underlying mechanism of high-mobility group box 1 (HMGB1), as an established
inflammatory mediator in acute rejection, remains poorly understood in chronic rejection.
Here, we assessed the effects and mechanisms of HMGB1 on the chronic rejection using
single MHC Class II-mismatched mouse cardiac transplantation model. It was found that …