[HTML][HTML] Methylation of the retinoblastoma tumor suppressor by SMYD2

LA Saddic, LE West, A Aslanian, JR Yates… - Journal of Biological …, 2010 - ASBMB
The retinoblastoma tumor suppressor (RB) is a central cell cycle regulator and tumor
suppressor. RB cellular functions are known to be regulated by a diversity of post-
translational modifications such as phosphorylation and acetylation, raising the possibility
that RB may also be methylated in cells. Here we demonstrate that RB can be methylated by
SMYD2 at lysine 860, a highly conserved and novel site of modification. This methylation
event occurs in vitro and in cells, and it is regulated during cell cycle progression, cellular …