Phospho-Ser/Thr-binding domains: navigating the cell cycle and DNA damage response

HC Reinhardt, MB Yaffe - Nature reviews Molecular cell biology, 2013 - nature.com
HC Reinhardt, MB Yaffe
Nature reviews Molecular cell biology, 2013nature.com
Coordinated progression through the cell cycle is a complex challenge for eukaryotic cells.
Following genotoxic stress, diverse molecular signals must be integrated to establish
checkpoints specific for each cell cycle stage, allowing time for various types of DNA repair.
Phospho-Ser/Thr-binding domains have emerged as crucial regulators of cell cycle
progression and DNA damage signalling. Such domains include 14-3-3 proteins, WW
domains, Polo-box domains (in PLK1), WD40 repeats (including those in the E3 ligase …
Abstract
Coordinated progression through the cell cycle is a complex challenge for eukaryotic cells. Following genotoxic stress, diverse molecular signals must be integrated to establish checkpoints specific for each cell cycle stage, allowing time for various types of DNA repair. Phospho-Ser/Thr-binding domains have emerged as crucial regulators of cell cycle progression and DNA damage signalling. Such domains include 14-3-3 proteins, WW domains, Polo-box domains (in PLK1), WD40 repeats (including those in the E3 ligase SCFβTrCP), BRCT domains (including those in BRCA1) and FHA domains (such as in CHK2 and MDC1). Progress has been made in our understanding of the motif (or motifs) that these phospho-Ser/Thr-binding domains connect with on their targets and how these interactions influence the cell cycle and DNA damage response.
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