[HTML][HTML] Porphyromonas gingivalis stimulates bone resorption by enhancing RANKL (receptor activator of NF-κB ligand) through activation of toll-like receptor 2 in …
A Kassem, P Henning, P Lundberg, PPC Souza… - Journal of Biological …, 2015 - ASBMB
Periodontitis has been associated with rheumatoid arthritis. In experimental arthritis,
concomitant periodontitis caused by oral infection with Porphyromonas gingivalis enhances
articular bone loss. The aim of this study was to investigate how lipopolysaccharide (LPS)
from P. gingivalis stimulates bone resorption. The effects by LPS P. gingivalis and four other
TLR2 ligands on bone resorption, osteoclast formation, and gene expression in wild type
and Tlr2-deficient mice were assessed in ex vivo cultures of mouse parietal bones and in an …
concomitant periodontitis caused by oral infection with Porphyromonas gingivalis enhances
articular bone loss. The aim of this study was to investigate how lipopolysaccharide (LPS)
from P. gingivalis stimulates bone resorption. The effects by LPS P. gingivalis and four other
TLR2 ligands on bone resorption, osteoclast formation, and gene expression in wild type
and Tlr2-deficient mice were assessed in ex vivo cultures of mouse parietal bones and in an …