[HTML][HTML] CXCR3 chemokine ligands during respiratory viral infections predict lung allograft dysfunction
SS Weigt, A Derhovanessian, E Liao, S Hu… - American Journal of …, 2012 - Elsevier
Community-acquired respiratory viruses (CARV) can accelerate the development of lung
allograft dysfunction, but the immunologic mechanisms are poorly understood. The
chemokine receptor CXCR3 and its chemokine ligands, CXCL9, CXCL10 and CXCL11
have roles in the immune response to viruses and in the pathogenesis of bronchiolitis
obliterans syndrome, the predominant manifestation of chronic lung allograft rejection. We
explored the impact of CARV infection on CXCR3/ligand biology and explored the use of …
allograft dysfunction, but the immunologic mechanisms are poorly understood. The
chemokine receptor CXCR3 and its chemokine ligands, CXCL9, CXCL10 and CXCL11
have roles in the immune response to viruses and in the pathogenesis of bronchiolitis
obliterans syndrome, the predominant manifestation of chronic lung allograft rejection. We
explored the impact of CARV infection on CXCR3/ligand biology and explored the use of …