[HTML][HTML] Interleukin-1α activity in necrotic endothelial cells is controlled by caspase-1 cleavage of interleukin-1 receptor-2: implications for allograft rejection
LC Burzynski, M Humphry, MR Bennett… - Journal of Biological …, 2015 - ASBMB
Inflammation is a key instigator of the immune responses that drive atherosclerosis and
allograft rejection. IL-1α, a powerful cytokine that activates both innate and adaptive
immunity, induces vessel inflammation after release from necrotic vascular smooth muscle
cells (VSMCs). Similarly, IL-1α released from endothelial cells (ECs) damaged during
transplant drives allograft rejection. However, IL-1α requires cleavage for full cytokine
activity, and what controls cleavage in necrotic ECs is currently unknown. We find that ECs …
allograft rejection. IL-1α, a powerful cytokine that activates both innate and adaptive
immunity, induces vessel inflammation after release from necrotic vascular smooth muscle
cells (VSMCs). Similarly, IL-1α released from endothelial cells (ECs) damaged during
transplant drives allograft rejection. However, IL-1α requires cleavage for full cytokine
activity, and what controls cleavage in necrotic ECs is currently unknown. We find that ECs …