[HTML][HTML] Gene set enrichment analysis identifies key innate immune pathways in primary graft dysfunction after lung transplantation
E Cantu, DJ Lederer, K Meyer, K Milewski… - American journal of …, 2013 - Elsevier
We hypothesized alterations in gene expression could identify important pathways involved
in transplant lung injury. Broncho alveolar lavage fluid (BALF) was sampled from donors
prior to procurement and in recipients within an hour of reperfusion as part of the NIAID
Clinical Trials in Organ Transplantation Study. Twenty-three patients with Grade 3 primary
graft dysfunction (PGD) were frequency matched with controls based on donor age and
recipient diagnosis. RNA was analyzed using the Human Gene 1.0 ST array. Normalized …
in transplant lung injury. Broncho alveolar lavage fluid (BALF) was sampled from donors
prior to procurement and in recipients within an hour of reperfusion as part of the NIAID
Clinical Trials in Organ Transplantation Study. Twenty-three patients with Grade 3 primary
graft dysfunction (PGD) were frequency matched with controls based on donor age and
recipient diagnosis. RNA was analyzed using the Human Gene 1.0 ST array. Normalized …