[HTML][HTML] ASC, a novel 22-kDa protein, aggregates during apoptosis of human promyelocytic leukemia HL-60 cells
J Masumoto, S Taniguchi, K Ayukawa… - Journal of biological …, 1999 - ASBMB
The cytoskeletal and/or nuclear matrix molecules responsible for morphological changes
associated with apoptosis were identified using monoclonal antibodies (mAbs). We
developed mAbs against Triton X-100-insoluble components of HL-60 cells pretreated with
all-trans retinoic acid. In particular, one mAb recognized a 22-kDa protein that exhibited
intriguing behavior by forming an aggregate and appearing as a speck during apoptosis
induced by retinoic acid and other anti-tumor drugs. Cloning and sequencing of its cDNA …
associated with apoptosis were identified using monoclonal antibodies (mAbs). We
developed mAbs against Triton X-100-insoluble components of HL-60 cells pretreated with
all-trans retinoic acid. In particular, one mAb recognized a 22-kDa protein that exhibited
intriguing behavior by forming an aggregate and appearing as a speck during apoptosis
induced by retinoic acid and other anti-tumor drugs. Cloning and sequencing of its cDNA …