[HTML][HTML] Interleukin 1 and interleukin 18 as mediators of inflammation and the aging process
CA Dinarello - The American journal of clinical nutrition, 2006 - Elsevier
In this review, 2 cytokines are discussed with respect to the inflammatory processes that are
fundamental to aging and mortality. Both interleukin (IL)-1 and IL-18 are members of the
same structural family (IL-1 family, or IL-F); there are presently 9 members of this family, but
with the exception of IL-1α, IL-1β, and IL-18, the others are antagonists or remain without
known function. IL-1α is an intracellular cytokine with properties of both a cytokine and a
transcription factor. IL-1β and IL-18 are closely related; both possess a similar three …
fundamental to aging and mortality. Both interleukin (IL)-1 and IL-18 are members of the
same structural family (IL-1 family, or IL-F); there are presently 9 members of this family, but
with the exception of IL-1α, IL-1β, and IL-18, the others are antagonists or remain without
known function. IL-1α is an intracellular cytokine with properties of both a cytokine and a
transcription factor. IL-1β and IL-18 are closely related; both possess a similar three …