[HTML][HTML] Oxidative stress disrupts insulin-induced cellular redistribution of insulin receptor substrate-1 and phosphatidylinositol 3-kinase in 3T3-L1 adipocytes: a …
A Tirosh, R Potashnik, N Bashan, A Rudich - Journal of Biological …, 1999 - ASBMB
In a recent study we have demonstrated that 3T3-L1 adipocytes exposed to low micromolar
H 2 O 2 concentrations display impaired insulin stimulated GLUT4 translocation from
internal membrane pools to the plasma membrane (Rudich, A., Tirosh, A., Potashnik, R.,
Hemi, R., Kannety, H., and Bashan, N.(1998) Diabetes 47, 1562–1569). In this study we
further characterize the cellular mechanisms responsible for this observation. Two-hour
exposure to∼ 25 μm H 2 O 2 (generated by adding glucose oxidase to the medium) resulted …
H 2 O 2 concentrations display impaired insulin stimulated GLUT4 translocation from
internal membrane pools to the plasma membrane (Rudich, A., Tirosh, A., Potashnik, R.,
Hemi, R., Kannety, H., and Bashan, N.(1998) Diabetes 47, 1562–1569). In this study we
further characterize the cellular mechanisms responsible for this observation. Two-hour
exposure to∼ 25 μm H 2 O 2 (generated by adding glucose oxidase to the medium) resulted …
