[HTML][HTML] PU. 1 is essential for p47 phox promoter activity in myeloid cells
SL Li, AJ Valente, SJ Zhao, RA Clark - Journal of Biological Chemistry, 1997 - ASBMB
Expression of the phagocyte cytosolic protein p47 phox, a component of NADPH oxidase, is
restricted mainly to myeloid cells. To study the cis-elements and trans-acting factors
responsible for its gene expression, we have cloned and characterized the p47 phox
promoter. A predominant transcriptional start site was identified 21 nucleotides upstream of
the translation initiation codon. To identify the gene promoter sequences, transient
transfections of HL-60 human myeloid cells were performed with a series of 5′-deletionp47 …
restricted mainly to myeloid cells. To study the cis-elements and trans-acting factors
responsible for its gene expression, we have cloned and characterized the p47 phox
promoter. A predominant transcriptional start site was identified 21 nucleotides upstream of
the translation initiation codon. To identify the gene promoter sequences, transient
transfections of HL-60 human myeloid cells were performed with a series of 5′-deletionp47 …
