Monogenic mutations differentially affect the quantity and quality of T follicular helper cells in patients with human primary immunodeficiencies

CS Ma, N Wong, G Rao, DT Avery, J Torpy… - Journal of Allergy and …, 2015 - Elsevier
Background Follicular helper T (T FH) cells underpin T cell–dependent humoral immunity
and the success of most vaccines. T FH cells also contribute to human immune disorders,
such as autoimmunity, immunodeficiency, and malignancy. Understanding the molecular
requirements for the generation and function of T FH cells will provide strategies for targeting
these cells to modulate their behavior in the setting of these immunologic abnormalities.
Objective We sought to determine the signaling pathways and cellular interactions required …