Mast cells contribute to initiation of autoantibody-mediated arthritis via IL-1

PA Nigrovic, BA Binstadt, PA Monach… - Proceedings of the …, 2007 - National Acad Sciences
PA Nigrovic, BA Binstadt, PA Monach, A Johnsen, M Gurish, Y Iwakura, C Benoist, D Mathis…
Proceedings of the National Academy of Sciences, 2007National Acad Sciences
Mast cells are immune sentinels that participate in the defense against bacteria and
parasites. Resident within the joint, mast cells become activated in human rheumatoid
arthritis and are implicated in the pathogenesis of experimental murine synovitis. However,
their arthritogenic role remains undefined. Using a model of autoantibody-induced arthritis,
we show that mast cells contribute to the initiation of inflammation within the joint by
elaboration of IL-1. Mast cells become activated to produce this cytokine via the IgG immune …
Mast cells are immune sentinels that participate in the defense against bacteria and parasites. Resident within the joint, mast cells become activated in human rheumatoid arthritis and are implicated in the pathogenesis of experimental murine synovitis. However, their arthritogenic role remains undefined. Using a model of autoantibody-induced arthritis, we show that mast cells contribute to the initiation of inflammation within the joint by elaboration of IL-1. Mast cells become activated to produce this cytokine via the IgG immune complex receptor FcγRIII. Interestingly, mast cells become dispensable for the perpetuation of arthritis after delivery of IL-1, highlighting the contribution of this lineage to arthritis induction. These findings illuminate a mechanism by which mast cells can participate in the pathogenesis of autoimmune inflammatory arthritis and provide insights of potential relevance to human rheumatoid arthritis.
National Acad Sciences