[HTML][HTML] Notch2 is preferentially expressed in mature B cells and indispensable for marginal zone B lineage development

T Saito, S Chiba, M Ichikawa, A Kunisato, T Asai… - Immunity, 2003 - cell.com
T Saito, S Chiba, M Ichikawa, A Kunisato, T Asai, K Shimizu, T Yamaguchi, G Yamamoto…
Immunity, 2003cell.com
The Notch genes play a key role in cellular differentiation. The significance of Notch1 during
thymocyte development is well characterized, but the function of Notch2 is poorly
understood. Here we demonstrate that Notch2 but no other Notch family member is
preferentially expressed in mature B cells and that conditionally targeted deletion of Notch2
results in the defect of marginal zone B (MZB) cells and their presumed precursors, CD1d hi
fraction of type 2 transitional B cells. Among Notch target genes, the expression level of …
Abstract
The Notch genes play a key role in cellular differentiation. The significance of Notch1 during thymocyte development is well characterized, but the function of Notch2 is poorly understood. Here we demonstrate that Notch2 but no other Notch family member is preferentially expressed in mature B cells and that conditionally targeted deletion of Notch2 results in the defect of marginal zone B (MZB) cells and their presumed precursors, CD1dhi fraction of type 2 transitional B cells. Among Notch target genes, the expression level of Deltex1 is prominent in MZB cells and strictly dependent on that of Notch2, suggesting that Deltex1 may play a role in MZB cell differentiation.
cell.com