The mode of action of metronidazole in Trichomonas vaginalis and other micro-organisms
RMJ Ings, JA McFadzean, WE Ormerod - Biochemical pharmacology, 1974 - Elsevier
RMJ Ings, JA McFadzean, WE Ormerod
Biochemical pharmacology, 1974•ElsevierRadioactivity from 14 C-metronidazole was quickly taken from the medium into cells of
Trichomonas vaginalis. It was rapidly metabolised by these organisms, largely to one
product, by removal of the 5-nitro group. Radioactivity from 14 C-metronidazole was also
bound to DNA and protein of T. vaginalis but not to RNA. Inhibition of nucleic acid synthesis
was demonstrated in both this and other drug-sensitive organisms at drug concentrations as
low as 1 μg/ml. A possible mechanism of action of the drug has been postulated.
Trichomonas vaginalis. It was rapidly metabolised by these organisms, largely to one
product, by removal of the 5-nitro group. Radioactivity from 14 C-metronidazole was also
bound to DNA and protein of T. vaginalis but not to RNA. Inhibition of nucleic acid synthesis
was demonstrated in both this and other drug-sensitive organisms at drug concentrations as
low as 1 μg/ml. A possible mechanism of action of the drug has been postulated.
Abstract
Radioactivity from 14C-metronidazole was quickly taken from the medium into cells of Trichomonas vaginalis. It was rapidly metabolised by these organisms, largely to one product, by removal of the 5-nitro group. Radioactivity from 14C-metronidazole was also bound to DNA and protein of T. vaginalis but not to RNA. Inhibition of nucleic acid synthesis was demonstrated in both this and other drug-sensitive organisms at drug concentrations as low as 1 μg/ml. A possible mechanism of action of the drug has been postulated.
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