Biology of claudins

S Angelow, R Ahlstrom, ASL Yu - American Journal of …, 2008 - journals.physiology.org
S Angelow, R Ahlstrom, ASL Yu
American Journal of Physiology-Renal Physiology, 2008journals.physiology.org
Claudins are a family of tight junction membrane proteins that regulate paracellular
permeability of epithelia, likely by forming the lining of the paracellular pore. Claudins are
expressed throughout the renal tubule, and mutations in two claudin genes are now known
to cause familial hypercalciuric hypomagnesemia with nephrocalcinosis. In this review, we
discuss recent advances in our understanding of the physiological role of various claudins in
normal kidney function, and in understanding the fundamental biology of claudins, including …
Claudins are a family of tight junction membrane proteins that regulate paracellular permeability of epithelia, likely by forming the lining of the paracellular pore. Claudins are expressed throughout the renal tubule, and mutations in two claudin genes are now known to cause familial hypercalciuric hypomagnesemia with nephrocalcinosis. In this review, we discuss recent advances in our understanding of the physiological role of various claudins in normal kidney function, and in understanding the fundamental biology of claudins, including the molecular basis for selectivity of permeation, claudin interactions in tight junction formation, and regulation of claudins by protein kinases and other intracellular signals.
American Physiological Society