Safety and tolerability of a novel inhaled GATA3 mRNA targeting DNAzyme in patients with TH2-driven asthma
U Homburg, H Renz, W Timmer, JM Hohlfeld… - Journal of Allergy and …, 2015 - jacionline.org
LETTERS TO THE EDITOR 797 possible, the observed events might also correspond to
mucosal irritation caused by inhalation of the nebulizer formulation. Other respiratory
complaints reported were cough (reported only in healthy subjects) and oropharyngeal pain
(all were mild and resolved spontaneously). No abnormal findings were reported in
electrocardiograms, safety laboratory parameters, or vital signs in any of the studies. The low
number of adverse events reported is consistent with the very low systemic exposure and …
mucosal irritation caused by inhalation of the nebulizer formulation. Other respiratory
complaints reported were cough (reported only in healthy subjects) and oropharyngeal pain
(all were mild and resolved spontaneously). No abnormal findings were reported in
electrocardiograms, safety laboratory parameters, or vital signs in any of the studies. The low
number of adverse events reported is consistent with the very low systemic exposure and …