[HTML][HTML] mSIN1 protein mediates SGK1 protein interaction with mTORC2 protein complex and is required for selective activation of the epithelial sodium channel

M Lu, J Wang, HE Ives, D Pearce - Journal of Biological Chemistry, 2011 - ASBMB
The mammalian target of rapamycin (mTOR) plays a central role in the regulation of a
number of cellular processes including growth, metabolism, and ion transport. mTOR is
found in two multiprotein complexes, mTORC1 and mTORC2, which phosphorylate distinct
substrates and regulate distinct cellular processes. SGK1 is an mTORC2 substrate, which is
a key regulator of epithelial Na+ transport mediated by the epithelial sodium channel.
Although it is known that SGK1 physically interacts with mTORC2, it is unknown which …