Chagas disease is one of the most serious parasitic diseases of Latin America, with a social
and economic impact far outweighing the combined effects of other parasitic diseases such
as malaria, leishmaniasis, and schistosomiasis. In the chronic phase of this disease, the
destruction of enteric nervous system components leads to megacolon development.
Besides neurons, the enteric nervous system is constituted by enteric glial cells,
representing an extensive but relatively poorly described population within the …