The protective effect of enteric glial cells on intestinal epithelial barrier function is enhanced by inhibiting inducible nitric oxide synthase activity under …
WD Xiao, W Chen, LH Sun, WS Wang, SW Zhou… - Molecular and Cellular …, 2011 - Elsevier
Enteric glial cells (EGC) play an essential role in maintaining the integrity of intestinal
epithelial barrier (IEB). However, the mechanism of EGCs in the regulation of IEB functions
under lipopolysaccharide (LPS) stimulation is unknown. To investigate the barrier-related
role of EGCs in response to the LPS challenge, the coculture model of EGCs and intestinal
epithelial cells (IEC) IEC-6 was established in vitro. Transepithelial resistance (TER)
measurements showed that, LPS treatment significantly increased barrier permeability of …
epithelial barrier (IEB). However, the mechanism of EGCs in the regulation of IEB functions
under lipopolysaccharide (LPS) stimulation is unknown. To investigate the barrier-related
role of EGCs in response to the LPS challenge, the coculture model of EGCs and intestinal
epithelial cells (IEC) IEC-6 was established in vitro. Transepithelial resistance (TER)
measurements showed that, LPS treatment significantly increased barrier permeability of …