Cyclic AMP signaling contributes to neural plasticity and hyperexcitability in AH sensory neurons following intestinal Trichinella spiralis-induced inflammation
Z Chen, Z Suntres, J Palmer, J Guzman, A Javed… - International journal for …, 2007 - Elsevier
Trichinella spiralis infection causes hyperexcitability in enteric after-hyperpolarising (AH)
sensory neurons that is mimicked by neural, immune or inflammatory mediators known to
stimulate adenylyl cyclase (AC)/cyclic 3′, 5′-adenosine monophosphate (cAMP)
signaling. The hypothesis was tested that ongoing modulation and sustained amplification in
the AC/cAMP/phosphorylated cAMP related element binding protrein (pCREB) signaling
pathway contributes to hyperexcitability and neuronal plasticity in gut sensory neurons after …
sensory neurons that is mimicked by neural, immune or inflammatory mediators known to
stimulate adenylyl cyclase (AC)/cyclic 3′, 5′-adenosine monophosphate (cAMP)
signaling. The hypothesis was tested that ongoing modulation and sustained amplification in
the AC/cAMP/phosphorylated cAMP related element binding protrein (pCREB) signaling
pathway contributes to hyperexcitability and neuronal plasticity in gut sensory neurons after …