Direct inhibition of type 5 adenylyl cyclase prevents myocardial apoptosis without functional deterioration
K Iwatsubo, S Minamisawa, T Tsunematsu… - Journal of Biological …, 2004 - ASBMB
Adenylyl cyclase, a major target enzyme of β-adrenergic receptor signals, is potently and
directly inhibited by P-site inhibitors, classic inhibitors of this enzyme, when the enzyme
catalytic activity is high. Unlike β-adrenergic receptor antagonists, this is a non-or
uncompetitive inhibition with respect to ATP. We have examined whether we can utilize this
enzymatic property to regulate the effects of β-adrenergic receptor stimulation differentially.
After screening multiple new and classic compounds, we found that some compounds …
directly inhibited by P-site inhibitors, classic inhibitors of this enzyme, when the enzyme
catalytic activity is high. Unlike β-adrenergic receptor antagonists, this is a non-or
uncompetitive inhibition with respect to ATP. We have examined whether we can utilize this
enzymatic property to regulate the effects of β-adrenergic receptor stimulation differentially.
After screening multiple new and classic compounds, we found that some compounds …
