Epac and phospholipase Cϵ regulate Ca2+ release in the heart by activation of protein kinase Cϵ and calcium-calmodulin kinase II
EA Oestreich, S Malik, SA Goonasekera… - Journal of Biological …, 2009 - ASBMB
Recently, we identified a novel signaling pathway involving Epac, Rap, and phospholipase
C (PLC) ϵ that plays a critical role in maximal β-adrenergic receptor (βAR) stimulation of Ca
2+-induced Ca 2+ release (CICR) in cardiac myocytes. Here we demonstrate that PLCϵ
phosphatidylinositol 4, 5-bisphosphate hydrolytic activity and PLCϵ-stimulated Rap1 GEF
activity are both required for PLCϵ-mediated enhancement of sarcoplasmic reticulum Ca 2+
release and that PLCϵ significantly enhances Rap activation in response to βAR stimulation …
C (PLC) ϵ that plays a critical role in maximal β-adrenergic receptor (βAR) stimulation of Ca
2+-induced Ca 2+ release (CICR) in cardiac myocytes. Here we demonstrate that PLCϵ
phosphatidylinositol 4, 5-bisphosphate hydrolytic activity and PLCϵ-stimulated Rap1 GEF
activity are both required for PLCϵ-mediated enhancement of sarcoplasmic reticulum Ca 2+
release and that PLCϵ significantly enhances Rap activation in response to βAR stimulation …
