[HTML][HTML] Analysis of the Short Consensus Repeats of Human Complement Factor B by Site-directed Mutagenesis (∗)
DE Hourcade, LM Wagner, TJ Oglesby - Journal of Biological Chemistry, 1995 - ASBMB
Human factor B is required for the initiation and propagation of the complement alternative
pathway. It also participates in the amplification of the complement classical pathway. Alone,
factor B is a zymogen with little known biochemical activity, but in the context of the
alternative pathway convertases, the factor B serine protease is activated in a process that
first involves the association with C3b and subsequently the cleavage of factor B into two
fragments, Ba and Bb. Ba, the NH 2-terminal fragment, is composed mainly of three tandem …
pathway. It also participates in the amplification of the complement classical pathway. Alone,
factor B is a zymogen with little known biochemical activity, but in the context of the
alternative pathway convertases, the factor B serine protease is activated in a process that
first involves the association with C3b and subsequently the cleavage of factor B into two
fragments, Ba and Bb. Ba, the NH 2-terminal fragment, is composed mainly of three tandem …
