Generating a Wnt switch: it's all about the right dosage
HA Kestler, M Kühl - Journal of Cell Biology, 2011 - rupress.org
Journal of Cell Biology, 2011•rupress.org
Wnt proteins can activate different branches of the Wnt signaling pathway, raising the
question of specificity. In this issue, Nalesso et al.(2011. J. Cell Biol. doi: 10.1083/jcb.
201011051) provide an answer to this conundrum by showing that different concentrations
of Wnt ligands can elicit different intracellular responses. These findings not only provide
new insights into the molecular mechanisms underlying Wnt signaling, but also indicate how
Wnt gradients might contribute to tissue patterning during embryogenesis.
question of specificity. In this issue, Nalesso et al.(2011. J. Cell Biol. doi: 10.1083/jcb.
201011051) provide an answer to this conundrum by showing that different concentrations
of Wnt ligands can elicit different intracellular responses. These findings not only provide
new insights into the molecular mechanisms underlying Wnt signaling, but also indicate how
Wnt gradients might contribute to tissue patterning during embryogenesis.
Wnt proteins can activate different branches of the Wnt signaling pathway, raising the question of specificity. In this issue, Nalesso et al. (2011. J. Cell Biol. doi:10.1083/jcb.201011051) provide an answer to this conundrum by showing that different concentrations of Wnt ligands can elicit different intracellular responses. These findings not only provide new insights into the molecular mechanisms underlying Wnt signaling, but also indicate how Wnt gradients might contribute to tissue patterning during embryogenesis.
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